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Isotretinoin for acne is incompatible with alcohol intake because of the risk of increased transaminases. Warn of this risk is advice that the pharmacist should address, especially young people with acne who take this medication, said Virginia Sanchez, head of the Dermatology Service of HM Sanchinarro . “He explains This increase occurs because the isotretinoin is metabolized primarily in the liver, also resulting in an increased cholesterol and triglycerides “. In this side effect, it is important to note that the dose of isotretinoin is being taken and the amount of alcohol consumed, and that the greater are both increased risk of liver damage.

  • Isotretinoin increases drug levels in blood and power effects

Transaminases increased by ingestion of isotretinoin can also be given without the need to drink alcohol, especially at the beginning of treatment. It is reversible, but if the rise exceeds two or three times the normal value would have to stopping treatment.

Maria Jose Alonso, a dermatologist from the Spanish Academy of Dermatology and Venereology (AEDV) says that alcohol “also increases drug levels in blood and strengthens its effects, causing an overdose .” Even when the dose of the drug is very low two days in week 20 mg, for example, the risk exists and “the same precautions should be taken because the half – life of the drug is prolonged and, although one day not been taken, it remains in the body” said Alonso. This does not mean it removed one hundred percent alcohol intake. “You can consume daily, but exceptionally well in an isolated occasion.” He says.

Experts remind that isotretinoin is a retinoid oral 13-cis isomer of retinoic acid and all-trans vitamin A pure. Sanchez specifies that “acts directly on the pilosebaceous unit, reducing the size of the sebaceous gland and regulating keratinization of the hair follicle, whose alteration is the leading cause of occurrence of acne.” As the amount of sebum is reduced, the bacteria Propionibacterium acnes decreases, reducing inflammation. The only item that does not work is hormonal.

On its effectiveness, Sanchez argues that “the first month of treatment acne may suffer some deterioration, but in the following months the improvement is usually spectacular.” In your experience, as well as remove acne, closes the pores and reduce the risk of outbreaks and intensity.


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