Almirall has announced the launch of Nano4Derm, a research project in collaboration with the Institute of Materials Science of Barcelona (ICMAB-CSIC) and the Leitat Technology Center focused on nanomedicine applied to the treatment of dermatological diseases.
Under this research project, new innovative formulations nanoencapsulated actives for topical treatment of inflammatory skin diseases, such as acne and psoriasis will develop.
Nano4Derm ranges from development and physicochemical and biological characterization of nanocapsules containing active ingredients, to the generation of a prototype scalable formulation for manufacturing nanoformulations suitable for clinical trials. These innovative formulations address remains and needs not currently covered, such as antimicrobial resistance, and to provide topical treatments for acne improved and psoriasis in terms of side effects, instability of the active ingredients and skin penetration.
According to the terms of the collaboration agreement, research centers ICMAB-CSIC and Leitat be responsible for developing various prototypes of nanocapsules containing active ingredients, while Almirall will be responsible for developing formulations containing encapsulated active. Furthermore, Almirall and LEITAT through preclinical studies evaluated both new nanocapsules as formulations in order to select the best solution to address unmet medical needs in the topical treatment for acne and psoriasis.
This collaboration will enable the development of two types of nanocapsules: quatsomas and polymeric nanocapsules. The quatsomas lipid nanoparticles are colloidal stability more liposomes, which favors obtaining high quality pharmaceutical formulations. These are obtained by Delos- Susp, a technology developed by researchers Nanomol group (ICMAB-Cisc) based on the use of supercritical fluids such as CO2 . This technology has many advantages over other methods of manufacturing in terms of uniformity and scalability, since it replaces the use of organic solvents by green solvents. On the other hand, polymeric nanocapsules, developed by the Leitat Technology Center, adds versatility to the project because they can be designed with different release profiles of the active ingredient depending on the need to tackle.
This project is funded by the Ministry of Economy, Industry and Competitiveness (Mineco) by Convocation 2016 the State Program of R + D + i, oriented societal challenges, modality Challenges-Collaboration 2016, and funded by FEDER funds the European Commission.